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KMID : 0903519950380060516
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1995 Volume.38 No. 6 p.516 ~ p.521
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Structure Elucidation of a Potent Anti - MRSA Antibiotic , AM3 , Produced by Streptomyces sp .
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김종훈/Kim, Jong Hoon
임융호/장준환/서정우/정재경/이철훈/Lim, Yoong Ho/Chang, Jun Hwan/Suh, Jung Woo/Jung, Jae Kyung/Lee, Chul Hoon
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Abstract
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In order to find a potent anti-methicillin resistant Staphylococcus aureus (MRSA) antibiotic, actinomycetes isolated from the samples collected in Korean marine silt were screened. From the culture broth of the isolated Streptamyces strain AM045, a substance showing excellent biological activity against MRSA was found, isolated and named AM3. The compound showed strong activities against MRSA, S. epideridis, E. faecium and E. faecalis, which were better than those of vancomycin and teicoplanin. Unfortunately, AM3 was identified as Actinomycin V. However, this paper reports the three dimensional study of AM3 based on high resolution nmr and Computer Aided Molecular Modeling(CAMM), and the fact that the structure of the pentapeptide lactone ring with oxo-proline in chloroform solution does not have $quot;C conformation$quot; any more.
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KEYWORD
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